Impact of plasma-activated PBS on human prostate cancer cell line and noncancer prostatic cell line
Kužmová D., Gbelcová H., Machala Z.
2nd Annual Meeting of COST Action PlasTHER “Therapeutical applications of cold plasmas”, Bologna, Italy, September 04-07, p. 74 (2023)
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Abstrakt: Patients with cancer go through difficult treatments that greatly disrupt their lives. Conventional therapies have a strong effect on different aspects of their well-being, such as their physical health, emotions, and overall quality of life. Ideally, an effective treatment modality should possess the ability to selectively target tumor cells, while minimizing harm to healthy cells, ensuring a higher level of resistance in normal tissue. Our research contributes to the growing field of plasma
medicine by exploring the potential of cold plasma and plasma-treated liquids as a therapeutic modality [1].
This study focuses on the impact of indirect application of cold plasma via plasma-treated liquids, which contain long-lived reactive oxygen and nitrogen species [2]. The primary objective is to compare the effects of plasma-activated phosphate-buffered saline (PAPBS) treated by cold atmospheric plasma of streamer corona discharge on a human prostate cancer cell line PC3 and human prostatic stromal myofibroblast cell line WPMY-1, used as noncancer cells. Various durations of plasma treating of liquid were examined, alongside different incubation times of cells with plasma-activated PBS. The aim was to assess the effects of these different treatment parameters on noncancer and cancer cells. The outcomes demonstrate a selective effect observed in the targeted cancer cells. Preliminary results of direct plasma treatment by pulsed streamer corona of PC3 and WPMY-1 cells will be also shown.
These findings may pave the way for the development of innovative and more targeted treatment approaches for prostate cancer and potentially other malignancies, aiming to efficient tumor removal and minimize the detrimental impact of therapies on their lives
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